|
Lexapro Lexapro
withdrawal description. Lexapro withdrawal solutions, Lexapro patient information
and Lexapro news. Lexapro withdrawal . How to avoid Lexapro
withdrawal and information, descriptions, Lexapro withdrawal, Lexapro weight gain.
Lexapro
Head symptoms? Anxiety? Insomnia? Of course you do.
You likely would prefer to cut to the chase and find
out what you can do to get relief quickly. Omega 3
Supreme has been formulated to help cut through
the head symptoms quickly.
Neuro Day is formulated for the daytime anxiety and
most other daytime side effects
Neuro Night for sleep and body aches
JNK Formula helps bring a gene back to balance the
medication has altered.
Go to the manufacturers web site
Click here and purchase; JNK
Formula, Neuro Day and Neuro Night and then get a
couple bottles of the Omega 3 Supreme. You will
be needing the extra omega's.
The
Road Back Program. Step by step procedure of how to taper
off or quit taking Lexapro and eliminate
Lexapro withdrawal
side effects. Click here
All other links open a new browser
window.
Lexapro: Full Lexapro
Description - Click
here
- Source:
FDA
Lexapro:
Increased Risk of Neonatal Persistent Pulmonary Hypertension
Click here -
Source:
FDA ALERT
[7/2006]
Lexapro:
Patient Information Click
here - Source:
FDA
Lexapro: Lexapro News Click here
Partial Lexapro description:
Pharmacokinetics
The single- and multiple-dose pharmacokinetics of Lexapro
are linear and dose-proportional in a dose range of 10 to 30
mg/day. Biotransformation of Lexapro is mainly hepatic, with
a mean terminal half-life of about 27-32 hours. With
once-daily dosing, steady state plasma concentrations are
achieved within approximately one
week.
At steady state, the extent of accumulation of
Lexapro
in plasma in young healthy subjects was 2.2-2.5 times the
plasma concentrations observed after a single dose. The
tablet and the oral solution dosage forms of Lexapro oxalate
are bioequivalent.
Absorption and Distribution
Following a single oral dose (20 mg
tablet or solution) of Lexapro, peak blood levels occur
at about 5 hours. Absorption of Lexapro is not affected
by food.
The absolute bioavailability of
citalopram is about 80% relative to an intravenous dose,
and the volume of distribution of citalopram is about 12
L/kg. Data specific on escitalopram are unavailable.
The binding of Lexapro to human plasma
proteins is approximately 56%.
Metabolism
and Elimination
Following oral administrations of Lexapro,
the fraction of drug recovered in the urine as Lexapro and S
- demethylcitalopram (S-DCT) is about 8% and 10%,
respectively. The oral clearance of Lexapro is 600 mL/min,
with approximately 7% of that due to renal clearance.
Lexapro is metabolized to S-DCT and S-didemethylcitalopram
(S-DDCT). In humans, unchanged Lexapro is the predominant
compound in plasma. At steady state, the concentration of
the Lexapro metabolite S-DCT in plasma is approximately
one-third that of Lexapro. The level of S-DDCT was not
detectable in most subjects.
In vitro
studies show
that Lexapro is at least 7 and 27 times more potent than S -
DCT and S-DDCT, respectively, in the inhibition of serotonin
reuptake, suggesting that the metabolites of Lexapro do not
contribute significantly to the antidepressant actions of
Lexapro.
S-DCT and S-DDCT also have no or very low affinity for
serotonergic (5-HT1-7) or other receptors
including alpha- and beta-adrenergic, dopamine (D1-5),
histamine (H1-3),
muscarinic (M1-5), and benzodiazepine
receptors. S-DCT and S-DDCT also do not bind to various ion
channels including Na+, K+, Cl-, and
Ca++ channels.
A full description can be found
Click
here -
Source: FDA
To visit the Lexapro
manufactures site
Click here
Other Lexapro info from the
FDA Click here
Study Of Drug Therapy For Compulsive
Buying Yields A Puzzle
Researchers at the Stanford
University School of Medicine say they are puzzled by
findings from their new study indicating that an
antidepressant, which previously showed promise in treating
a behavioral disorder known as compulsive buying, did not
result in a sustained benefit for the patients who took it.
The medication is Lexapro, a commonly
prescribed antidepressant sold under the brand name Lexapro.
In the study, researchers found no difference in the relapse
rate of people with compulsive-buying disorder when they
continued to take Lexapro compared with those who had been
switched to a placebo. Those results are perplexing to lead
author Lorrin Koran, MD, professor of psychiatry and
behavioral sciences emeritus, because he had done a similar
study in 2003 that found compulsive-buying patients improved
stably after taking another antidepressant medication,
citalopram, in which Lexapro is the active ingredient.
"It was a shock that, when we did the
trial again with the active ingredient, it didn't work
exactly the same way. It should have," said Koran, who also
led the 2003 study. The results of the latest double-blind,
placebo-controlled trial will be published in the April
issue of the Journal of Clinical Psychopharmacology.
Koran said the unexpected result from the
new study may in part be due to the small number of
participants in the double-blind phase of the trial, which
involved just 17 subjects whose buying behavior had markedly
improved in the initial stage of the trial when they were
all taking Lexapro. Of the nine randomly assigned to take a
placebo in the later part of the trial, six relapsed, while
five of eight continuing on Lexapro relapsed.
But the study size is likely not the only
factor influencing the outcome of the trial.
"I don't think we're dealing with one
pure biological disorder," said Koran. "We're dealing with a
behavior that has different biological roots in different
people and therefore we may have had very different groups
of people in the two studies."
In the 2003 study, 24 patients were all
initially given citalopram for the open-label portion of the
study, during which they all knew they were taking
citalopram. Fifteen of those patients reported marked
improvements in their buying behaviors. For the second
portion of that trial, these 15 patients were randomly
assigned to take either citalopram or a placebo without
knowing which one they were taking. Of seven patients who
continued taking the medication, all seven maintained their
improvement, while five of the eight patients receiving a
placebo relapsed.
People suffering from compulsive buying
disorder are preoccupied with shopping for unneeded items
and are frequently unable to resist purchasing them. The
problem is not a simple lack of willpower, said Koran, who
described it as being as real a disorder as other impulsive
behaviors such as alcoholism and pathological gambling.
Sufferers of the disorder commonly wind up with closets or
rooms filled with unwanted purchases, amassing thousands of
dollars of debt in the process and often damaging their
relationships by lying to loved ones about their purchases.
A recent nationwide, random-sample
telephone survey conducted by Koran and his colleagues
indicated that compulsive buying appeared to affect nearly 6
percent of the U.S. population, with nearly equal
proportions of men and women affected.
Koran said a larger double-blind,
placebo-controlled clinical trial is needed to reach a
conclusive result regarding the effectiveness of Lexapro in
treating patients with compulsive buying disorder.
He suggested future clinical trials might
be able to yield more information if they were combined with
imaging studies of the patients' brains. He cited recent
work by Brian Knutson, PhD, assistant professor of
psychology and neuroscience, whose recent imaging studies
suggest that scientists might be able to directly visualize
brain activity related to compulsive purchases.
"We would look for a difference in the
brain activation patterns of those who respond to the drug
vs. those who don't," said Koran.
The inconclusive nature of the results
from the latest trial of Lexapro should not discourage
anyone suffering from compulsive buying from seeking
treatment, since several types of treatment seem to be
helpful, Koran emphasized.
Other co-authors include Hugh Brent
Solvason, MD, PhD, assistant professor of psychiatry and
behavioral sciences; Nona Gamel, clinical research manager;
and Emily Smith, clinical research coordinator.
Note: This story has been adapted from a news release issued
by Stanford University Medical Center.
Lexapro side effects and
Lexapro withdrawal side effects
-
- - Anorexia – No longer having a desire
to eat.
-
- - Apothous
Stomatitis – Painful red and swollen open sores on a
mucus membrane of the mouth commonly called a canker
sore.
-
- - Ataxia –
Loss of the ability to move the body with coordination.
-
- - Arterial
Fibrillation – A condition of abnormal twitching of
the muscles in the blood vessels that moves the
oxygenated blood from the heart to the rest of the
body. The unusual twitching is rapid and irregular and
replaces the normal rhythm of contraction of the muscle,
which sometimes causes a lack of circulation and pulse.
-
- - Blood
Cholesterol Increased – An abnormal condition where
there is a greater amount in the blood of the oily/fatty
substances known as cholesterol. Cholesterol is a
necessary part of living cells (along with proteins and
carbohydrates). Because cholesterol only slightly
dissolves in water, it can build up on the walls of the
blood vessels, therefore blocking/decreasing the amount
of blood flow, which causes blood pressure to go up. If
not corrected, this condition is associated with
coronary artery disease.
-
- - Blood
Creatinine Increased – A greater than normal number
of creatinine or muscular chemical waste molecules in
the blood. Creatinine plays a major role in energy
production in muscles. Since creatinine levels are
normally maintained by the kidneys, Blood Creatinine
Increased is an indicator of kidney malfunction or
failure.
-
- - Blood in
Stool – The blood that is in your bowel movement
usually comes from any place along your digestive tract
(from your mouth to your anus). The stool can appear
black and foul-smelling (usually from the upper part of
your digestive tract) or red or maroon-colored (usually
from the large intestine area). Hemorrhoids are the
usual cause for blood in the bowels.
8. - - Bundle Branch
Block Right – These are specialized cells in the upper
right heart chamber and are the heart’s pacemaker.
They send electrical signals to the heart that keeps it
beating or contracting regularly. Normally the signal
goes to the lower heart chambers at the same time through
the bundle of His (hiss) on both the left and right sides of
the heart, so the lower chambers contract at the same time.
When the bundle is damaged on the right side, the signal
does not fire at the same time as the left, which changes
the pace of blood flow. This can lead to a person
fainting.
-
- - Cardiac Failure – A heart disorder
where the heart does not function as usual and may
completely stop working.
-
- - Cardiac
Failure Congestive – The body is asking for the
heart to supply more blood than it is capable of
producing and maintaining. Normally, a body can
tolerate an increased amount of work for quite some
time. The condition is characterized by weakness,
shortness of breath, and a fluid build-up in the body
tissues causing swelling.
-
- - Cold Sweat
– The skin is clammy and moist and you feel chilled.
This is a reaction to a shock or pain as well as to fear
and nervousness.
-
- - Colitis –
A condition where the large intestine becomes irritated
from the use of the drug.
-
- - Coronary
Artery Disease – A condition where the blood vessels
that mainly carry the blood away from the heart become
clogged up or narrowed usually by fatty deposits. The
first symptom is pain spreading from the upper left body
caused by not enough oxygen reaching the heart.
-
- - Dehydration
– An extreme loss of water from the body or the organs
of the body as in sickness or not drinking enough
fluids.
-
- - Diplopia
– The condition where a person is looking at one object
and instead of normally seeing just the one object he
sees two. This is also called double vision.
-
- -
Diverticulitis – There are pouches or sacs on the
inside of the intestines that look like fingers. This
increases the area for the body to absorb nutrients as
they pass through the intestines. These sacs become
irritated and swollen and end up trapping waste that
would normally be eliminated, causing pain and
constipation.
-
- - Dysarthria
– The inability to control the mouth muscles when
forming words so the words are not clearly spoken and
heard.
-
- - Dyslipidemia
– The normal fat metabolism in the blood is interfered
with.
-
- - Dysphagia
– Trouble swallowing or the inability to swallow.
-
- - Ecchymosis
– When a blood vessel breaks and creates a purple
discoloration of the skin.
-
- - Edema –
An abnormal build up of excess fluids in the cells,
tissues, and the spaces between the tissues creating
swelling.
-
- - Edema
Peripheral – The abnormal build up of fluids in the
tissues of the ankles and legs causing painless swelling
in the legs, ankles, and feet. If you squeeze the
swollen area it leaves an indentation on the skin for a
few minutes.
-
- - Ejaculation
Delayed – The man is not able to release sperm
either during sexual intercourse or with manual
stimulation in the presence of his sexual partner in
spite of his wish to do so.
-
- - Ejaculation
Dysfunction – A condition where the man has one or
more of the following symptoms: He is not able to have
an erection, not able to have an orgasm, has a decreased
interest in sex, is sexually inhibited, or it is painful
to ejaculate sperm.
-
- - Erectile
Dysfunction – Incapable of having sexual
intercourse. Even though a man desires sex he is
inhibited in his sexual activity and is unable to have
or maintain an erection of the penis.
-
- - Erythema
– a skin redness caused by the swelling with blood of
the tiny blood vessels of the skin as in burns.
-
- - Erythematous
Rash – Redness of the skin from the swelling of the
tiny blood vessels with skin irritation (itching,
burning, tingling, pain) and breakouts (eruptions).
-
- - Esophageal
Stenosis Acquired – The tube that moves food from
the mouth to the stomach narrows.
-
- - Exfoliative
Dermatitis – The unusual and not normal condition of
scaling and shedding of the skin cells. The skin is
usually red colored.
-
- - Face Edema
– The tissues of the face become swollen.
-
- - Feeling
Jittery – A physical sensation of nervous unease.
-
- - Gastric
Irritation – An inflamed and sore stomach.
-
- - Gastric Ulcer
– An open, irritated, and infected sore in the wall of
the stomach.
-
- - Gingivitis
– Sore, swollen and red gums in the mouth that bleed
easily.
-
- - Glaucoma
– The delicate nerve to the eye, the optic nerve,
becomes easily damaged with the build-up of excess fluid
pressure within the eyeball. The first sign of glaucoma
is loss of peripheral (side) vision. It can progress to
total blindness.
-
- - Hepatic
Steatosis – Excessive amounts of fat in the liver.
-
- - Hyperhidrosis
– The triggering of an excess of sweat being produced on
the soles of the feet, the palms, or the underarms which
can cause embarrassment or losing grip on a pen or other
items.
-
- -
Hyperkeratosis – An abnormal enlargement of the skin
tissues causing the skin cells to increase in size.
-
- -
Hyperlipidemia – An abnormally high number of fat
cells in the blood.
-
- -
Hypertriglyceridemia – Too many triglycerides in the
blood.
Triglycerides are three fatty acids bound
together in one molecule stored by the body and available to
create high levels of energy when used.
-
- - Hypoesthesia – A partial loss of
sensation or general loss of awareness.
-
- - Impaired
Gastric Emptying – The contents of the stomach are
not passed into the intestines as normal due to the
stomach losing the muscular strength to do so.
-
- - Increased
White Blood cell Count – This is an increase in the
number of cells in the blood that are responsible for
the removal of bacteria and other unwanted particles.
They fight disease and infection by enclosing foreign
particles and removing them. An example of a disease
that would increase white blood cell count would be
Leukemia.
-
- - Insomnia
– Not able to fall asleep or sleeping for a shorter time
than desired, thus not being able to properly rest and
feeling un-refreshed. As a result, a person can become
irritable, have difficulty concentrating and feel a lack
of energy. This can be caused by stimulants such as by
caffeine or drugs or by mental anxiety and stress.
Mental stress can be communicated and relieved.
-
- - Irritable
Bowel Syndrome – A painful condition where either
the muscles or the nerves of the lower intestines, are
not responding normally. This results in an alternating
condition of diarrhea followed by constipation, back and
forth.
-
- -
Keratoconjunctivitis Sicca – A condition where the
outer coating of the eyeball is dry because of a
decrease in the normal amount of tears in the eye. As a
result, the eyeball and inside of the eyelid thickens
and hardens sometimes causing the vision to be less
sharp.
-
- - Leukopenia
– An unnaturally low number of white blood cells
circulating in the blood.
-
- - Loose Stools
– The bowel movement is runny instead of formed.
-
- - Lower
Abdominal Pain – A hurtful irritation of the nerve
endings in the area of the hipbones housing the lower
digestive tract. Pain usually means tissue damage.
-
- -
Lymphadenopathy – The lymph nodes, where the immune
cells are located, become larger than is normal because
of a high concentration of white blood cells.
-
- - Macular
Degeneration – The gradual loss of central vision,
which is the sharpest vision while peripheral eyesight,
is unaffected.
-
- - Maculopathy
– An abnormal condition of the yellow spot of the eye,
which is located in the center of the inner lining of
the eyeball and connected to the main nerve to the eye
and is responsible for sharp vision.
-
- - Mania –
Unusually irrational, excessive and/or exaggerated
behavior or moods ranging from enthusiasm, sexuality,
gaiety, impulsiveness and irritability to violence.
-
- - Melena –
Abnormally darkly colored stools as a result of
hemorrhaging in the digestive tract where the blood has
interacted with the digestive juices creating the dark
color in the bowel movement.
-
- - Micturition
Urgency – A sudden desire to urinate usually
followed by leakage.
-
- - Mood Swings
– An emotional shifting as from a state of happiness to
a state of depression for a period of time.
-
- - Myocardial
Infarction – The blood going to the heart is delayed
or stopped causing middle muscle tissue in the heart
wall to die.
-
- -
Nasopharyngitis – Irritation, redness and swelling
tissues in the nose and the tube leading from the mouth
to the voice box as well as the tubes leading to the
ears.
-
- - Nephropathy
– An abnormally functioning or diseased kidney.
-
- - Nervousness
– Jumpy, jittery, anxious, and troubled with an
irritable temperament.
-
- - Night Sweats
– The water-salt, waste product the skin releases is
called sweat or perspiration. With night sweats you
become wide awake in the middle of the night shivering
and cold and wet with your sheets/pajamas soaked in
perspiration making it difficult to go back to sleep.
-
- - Nightmare
– Dreams that make you afraid or leave feelings of fear,
terror, and upset long after waking up.
-
- - Orgasm
Abnormal – Unable to have an orgasm with normal
sexual stimulation.
-
- - Oropharyngeal
Swelling – A swelling in the area from the soft part
of the roof of the mouth to the back of the mouth.
-
- - Pain in
Extremity – A painful feeling in the legs, arms,
hands, and feet.
-
- -
Pharyngolaryngeal Pain – Pain in the area of the
respiratory tract (organs of breathing) from the throat
to the voice box and above the windpipe.
-
- - Photopsia
– A condition where a person see lights, sparks or
colors in front of your eyes.
-
- -
Photosensitivity Reaction – An exaggerated sunburn
reaction that is not normal in proportion to the amount
of exposure to the light.
-
- - Pollakiuria
– Urinating much more frequently than normal – as often
as once every five to fifteen minutes.
-
- - Pressure of
Speech – A condition where the individual cannot
voice his ideas fast enough with the pressure of there
being not enough time to say it.
-
- - Pruritic Rash
– Extremely itchy, red, swollen bumps on the skin.
-
- - Pyrexia –
Fever or the increase in body temperature that is
usually a sign of infection.
-
- - Retinal
Detachment – The thin layer lining the back of the
eyeball (the retina) detaches from the back of the
eyeball. This thin layer is like the film of a camera
because it sends the images a person views to the
brain. When it detaches it causes a reduced ability to
see.
-
- - Rigors –
Shivering or shaking of the body as if chilled,
preventing normal responses.
-
- - Skin Ulcer
– An open sore or infected skin eruption with swelling,
redness, pus, and irritation.
-
- - Sleep
Disorder – These are a list of sleep disorders such
as teeth grinding, insomnia, jet lag, sleep walking,
abnormally falling asleep during the middle of a
conversation after a full night’s rest, uncontrolled
body motions keeping one awake, etc.
-
- - Suicide,
Completed – An attempted attack on oneself that is
life threatening resulting in death.
-
- - Upper
Respiratory Tract Infection – Where the organs of
breathing near the mouth such as the nose and sinuses,
become infected and are usually treated by antibiotics.
-
- - Urinary
Hesitation – Hard to start or hard to continue
emptying one’s bladder.
-
- - Urinary
Incontinence – Urinating without intending to do so
because of a weakening of the muscles in the hip area
from the drug affecting the nerves or the drug blocking
a persons thinking process.
-
- - Urinary
Retention – The inability to completely empty the
bladder despite having the urge to do so. This can lead
to infections or damage to the urinary organs.
-
- - Urine Flow
Decreased – Dehydration of the body causing a lesser
flow of urine than normal with the body reabsorbing the
waste.
-
- - Urine Output
Decreased – A condition where the output of urine
produced in a 24-hour period is less than 500 ml.
-
- - Weight
Decreased – Unintentional weight loss.
-
- – Weight
Increased – An unusual, usually rapid weight
increase.
|
|