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Trintellix Vortioxetine Withdrawal

Trintellix, also known as vortioxetine, is a medication used to treat major depressive disorder. It is classified as a selective serotonin reuptake inhibitor (SSRI) and is approved by the FDA for use in adults. While Trintellix is generally well-tolerated, some people may experience withdrawal symptoms when discontinuing the medication.

Withdrawal symptoms can occur when a person stops taking a medication abruptly or reduces the dosage too quickly. Symptoms can vary in intensity and duration depending on the individual and their level of dependence on the medication. Trintellix withdrawal symptoms may include:

Dizziness or lightheadedness

Nausea or vomiting


Anxiety or nervousness

Insomnia or sleep disturbances

Irritability or agitation

Flu-like symptoms such as fatigue, muscle aches, and sweating

Electric shock sensations, also known as brain zaps

It is important to note that not everyone will experience withdrawal symptoms when stopping Trintellix, and some people may have a more severe experience than others.

To minimize the risk of withdrawal symptoms, it is important to follow the recommended dosing instructions when taking Trintellix. If a person decides to stop taking the medication, they should work with their healthcare provider to gradually taper off the medication over a period of several weeks or months. This gradual approach can help minimize the risk of withdrawal symptoms and allow the body to adjust to the changes in medication.

If a person does experience withdrawal symptoms, they should contact their healthcare provider for advice and support. In some cases, the healthcare provider may recommend restarting the medication and tapering off more slowly.

In conclusion, Trintellix withdrawal symptoms can occur when a person stops taking the medication or reduces the dosage too quickly. Symptoms can vary in intensity and duration depending on the individual and their level of dependence on the medication. To minimize the risk of withdrawal symptoms, it is important to follow the recommended dosing instructions and work with a healthcare provider to gradually taper off the medication. If a person does experience withdrawal symptoms, they should seek medical advice and support.

While Trintellix is generally well-tolerated, there have been some concerns about its negative effects on the JNK gene.

The JNK (c-Jun N-terminal kinase) gene is a protein that is involved in a variety of cellular processes, including inflammation and cell death. In recent years, there has been increasing interest in the role of JNK in the development of depression and other mood disorders. Some studies have suggested that JNK may be overactive in people with depression, and that this overactivity may contribute to the symptoms of the condition.

There is some evidence to suggest that Trintellix may have negative effects on the JNK gene. Specifically, some studies have found that Trintellix can activate JNK and increase its activity in certain brain regions. This activation may contribute to the development of certain side effects associated with the medication, such as nausea and vomiting.

While the exact mechanisms underlying the relationship between Trintellix and JNK are not fully understood, it is thought that the medication may interfere with the normal regulation of JNK activity in the brain. This interference could potentially lead to the overactivation of JNK and the development of negative side effects.

Trintellix Withdrawal Solution, Side Effects, Treatment OptionsTrintellix Withdrawal SymptomsThe majority of people attempting Trintellix withdrawal experience an antidepressant withdrawal syndrome. This is also known as Trintellix discontinuation syndrome in the United States. In Europe it is call Trintellix withdrawal side effects. The F.D.A. estimates 10% of those experiencing Trintellix withdrawal will go back up on the Trintellix because the withdrawal symptoms are too severe.The most common and debilitating Trintellix withdrawal side effect is called "brain zaps." Brain zaps are described by people experiencing it as a; electrical jolt that tends to run from base of the neck up into their head. Another side effect that tends to run with brain zaps is a shiver, a feeling as your head is floating, dizziness, and/or a whirling sensation in the head.

These symptoms can come in waves or even be persistent.

The good news; in 2002, our founder, Jim Harper, discovered the correct type of Omega 3 taken in the right quantity will eliminate these devastating head symptoms quickly. Usually within a couple of hours.The body in a normal state uses the oil from our diet, specifically from omega 3 found in fish, to build and replenish the end point of areas in the brain that sends and receives electrical signals.

We are using easy to understand terminology here so it is easy to understand. Let's leave the technical jargon to physicians. These brain zaps have nothing to do with serotonin levels or other made up reasons. It is simple really; our body works in a very natural way with how it uses amino acids, proteins, fats in food and all other diet items to maintain a balance.

When you introduce any toxin that disrupts these processes the body reacts. The most common Trintellix withdrawal symptoms reported include:

Flu like symptoms



Brain zaps




Increased suicidal ideation





Ringing in the ears




Mood swings

Please note: These are the most common Trintellix withdrawal side effects but far from all potential Trintellix withdrawal side effects.

There is a warning the FDA has put a black box warning on Trintellix. WARNING: SUICIDAL THOUGHTS AND BEHAVIORS

See full prescribing information for complete boxed warning.

Antidepressants increased the risk of suicidal thoughts and behaviorsin pediatric and young adult patients (5.1) Closely monitor for clinical worsening and emergence of suicidal thoughts and behaviors

You may have been prescribed Trintellix within a very short doctor visit. There was no investigation into other life factors, lab testing, or any conversation about what side effects might present. The failings of this approach may cause quite a burden on the patient.

Depression, insomnia, anxiety, fibromyalgia, and other symptoms that Trintellix is often prescribed for might stem from; diminished vitamin D levels, over active JNK gene, specific proteins that need to be silenced, dietary concerns and food allergies, mitochondrial dysfunction, neurotoxic accumulation, and many other reasons.

A full physical from an understanding physician is ideal, before prescribing Trintellix.

Do Your Symptoms Require Trintellix?

The Road Back Program uses nutritional supplements to help with the Trintellix withdrawal. Most people feel a very fast relief from the Trintellix withdrawal once they begin taking the supplements and we feel the odds are high; if you would have taken nutritional supplements like these before starting the Trintellix you would not have been prescribed the Trintellix in the first place.

"How Do You Survive Trintellix Withdrawal?

Surviving Trintellix withdrawal depends on what you do at this very moment. If you keep doing the same thing you have been doing and you are in a heavy Trintellix withdrawal, nothing will change for the positive, That is a given.

If you decide to do the Trintellix withdrawal as an inpatient in a drug rehab center DO NOT DO THE 9 DAY PLAN BECAUSE THAT WHAT INSURANCE ALLOWS. Over the past 22 years I have worked with far to many people who were sold on a rehab facility, stayed the 9 days because insurance would only pay for that amount of time. The unscrupulous facility took them off the Trintellix in 9 days as they promised and by the time the person got off the airplane after their return home they were in full withdrawal. You can't do a Trintellix withdrawal in 9 days.

The Road Back Program can normally help you get back on your feet again but the rehab facility approach of this type is not worth the price you will pay mentally and physically.

You will find a few other outpatient Trintellix withdrawal programs on the internet now and Jim Harper is not aware of one that will cause you harm like the rehab facility's mentioned. However, every other program on the internet was trained by Jim Harper years ago and they are doing what Jim Harper and The Road Back did during that time frame. Almost 2 decades ago Jim Harper trained several physicians and good intentioned people how to get a patient off antidepressants. Jim went in to detail of the process and what nutritional supplements were used and why they were used. At that time of The Road Back the success rate was not as high as desired and over the following years Jim changed the formulas used with the supplements several times to use new information with DNA testing.

Long story short; you will likely wind up using a Trintellix withdrawal approach The Road Back used in 2003, that was scrapped for something more successful. If you are currently in Trintellix withdrawal, send Jim Harper an email and he will personally guide you through the process so you can get back on your feet quickly and have a very successful Trintellix withdrawal.

It does not matter if you have been on Trintellix for 1 month years. Recovery can happen and the good part is; it does not take more time because you have been taking Trintellix for years.

When Do Trintellix Withdrawal Symptoms Start When Discontinuing / Quitting Trintellix?

Trintellix withdrawal usually begins between day 1 and day 3 of adjusting the Trintellix. For some people this is not the case but eventually most everyone hits some dosage of the Trintellix when reducing that jars them. Trintellix withdrawal begins and they have no idea what they should do. Their physician does not know what to do. They wind up in a spiral downward and wind up on a new medication to try and stop the Trintellix withdrawal.

The best case is the additional drug does that but you are now on 2 drugs instead of only Trintellix.

What is Trintellix?

This SSRI drug is prescribed in treating adult depressive disorders (MDD), panic disorder, obsessive compulsory disorders (OCD), social anxiety (SAD), post-traumatic stress disorders (PTSD), and premenstrual dysphoric disorder (PMDD).If you have anxiety before taking Trintellix, or anxiety begins while taking Trintellix, odds are the anxiety will continue to get worse. Trintellix alters dopamine and anxiety is a byproduct of these two drugs.

Trintellix Withdrawal, What to Expect

If using The Road Back Program you should expect to feel a lot better within the first couple days of the program. If you do nothing, expect to continue to feel as you do now. Possibly worse as time goes on. The chance of feeling better if you do nothing is nil.

In 1999, The Road Back only had people taper the antidepressants gradually and slowly. They still suffered. Around 50% could get off the Trintellix but most went back on the Trintellix because they continual Trintellix withdrawal side effects would not diminish or go away.We wish there was a better answer for you than the above but with working with over 19 million people over the last 22 years, the truth is the truth.

No way to water it down to make it sound better.

Some may think it is just their depression returning but who would not feel depressed if they were still going through Trintellix withdrawal months after stopping the Trintellix. We can't stress enough; what you do or do not do at this moment in time is critical for your future. Take your time if at all possible. If you have brain zaps go buy any omega 3 fish oil, even the wrong omega 3 fish oil will help somewhat. While you read this you may want to pause and go take a walk. Look at the trees, the sky or anything off in the distance. Getting your attention off your mind and body may do wonders. Keep this close to your heart; There is Hope and There is a Solution. We are speaking directly to YOU.

A 30 day supply of the nutritional supplements will cost you around $80. If you feel it is worth $80 to take a chance that all of this can go away in a couple of days, then take that chance. Over the past 22 years many have sent an email to Jim Harper and said they were not sure what to do about the Trintellix withdrawal. Even after reading this information. The people that tried something else generally came back within a few months and were in worse shape than before. We do not want this to happen to you. But if is; Jim will still be here to assist.

For safe Benzodiazepine or Trintellix withdrawal, either of these drugs must be slowly tapered to allow the central nervous system and neurochemistry to safely normalize.Choosing to withdrawal from the Trintellix first or the benzodiazepine first needs to be evaluated. Use Chapter 23, The Science to decide is part of that equation. Depending on the benzodiazepine you may be taking with the Trintellix, if you reduce the Trintellix first it may make you go into withdrawal on the benzodiazepine, even if you did not reduce the benzodiazepine.

There is Hope and There is a Solution